Skip to content
Transforming Health Care in Massachusetts

Transforming Health Care in Massachusetts

Overview

In Massachusetts, significant health care affordability challenges persist. The Massachusetts Life Sciences Center (MLSC), in collaboration with the Division of Insurance (DOI) and the Executive Office of Economic Development (EOED), is issuing this Request for Information (RFI) from stakeholders regarding innovative approaches to managing high-risk claimants within the Commonwealth’s unique merged health insurance market. The objective is to explore models that facilitate early intervention and high-quality care for high-risk individuals while achieving premium reductions for the broader merged market risk pool.

Driven by the foundational principles of health care affordability and equity, the primary goals of this RFI are to:

  1. Evaluate high-risk claimant management mechanisms (e.g., reinsurance, risk-pooling) suitable for the Massachusetts merged market, including, e.g., exploring potential long-term funding mechanisms that ensure high-quality patient care and meaningful premium relief for the remainder of the merged market.
  2. Identify innovative models for the reimbursement and funding of early intervention and care management for high-risk claimants.
  3. Assess potential cost savings for the remaining patients within the merged market risk pool upon separating out and reinsuring high-risk claimants.
  4. Understand barriers to implementation and necessary changes to address them.

Key Focus Areas

  • Proposed Models for High-Risk Claimant Management
  • Funding Mechanisms
  • Patient Protection and Care Management
  • Financial and Cost Savings Analyses
  • Implementation Considerations

Request for Information

The MLSC is committed to enhancing health equity across Massachusetts and increasing visibility of the ecosystem, including providers, payers, patients, innovators, and other industry and actuarial stakeholders who may support and advance our mission to close the health care divide. There is a unique opportunity to leverage the state’s health care and life sciences ecosystems with the Life Sciences 3.0 initiative that was passed with the Mass Leads Act.

As part of its efforts, the MLSC is issuing this RFI to receive feedback and insight from market participants and any other interested parties focused on promoting important health care equity and inclusion principles. Specifically, the MLSC is soliciting ideas that principally drive at furthering equitable, accessible, and affordable health care and health care coverage.

Interested Respondents may currently operate in Massachusetts but are not required to operate exclusively in Massachusetts. Interested Respondents are encouraged to collaborate in preparing a response to the RFI, and the MLSC welcomes combined submissions from multiple stakeholders.

The objective is to improve healthcare outcomes and cost efficiencies by exploring the creation of a high-risk claimant management mechanism that supports sustainable models of care within the Commonwealth’s merged market. Key principles underlying a potential mechanism include ensuring early intervention and access to emerging technologies and therapies for high-risk enrollees, as well as promoting high-quality care investments over time.

RFI feedback may help shape possible future program initiatives at the MLSC or policy ideas within the Commonwealth.

Submission Guidelines

  • Format: Responses must be submitted through the online form which can be accessed here.
  • Submission and Deadline: Responses must be submitted via the online form located here. The deadline for submission has been extended until Oct. 31, 2025 at 5 p.m. ET.
  • FAQs

Confidentiality

Please clearly label any proprietary information in your submission. The MLSC, DOI, and EOED will treat all submissions in accordance with applicable public records laws and their governing statutes.

Disclaimer
This RFI is for informational purposes only and does not constitute a solicitation or obligation to fund any proposals. Responses will inform the development of potential future initiatives but do not guarantee selection or funding.

Accelerating Research through Collaboration (ARC) Awards

Accelerating Research through Collaboration (ARC) Awards

Accelerating Research through Collaboration (ARC) Awards

The application period will run from Aug. 5 – Nov. 21, 2025 at 1 p.m. EST.

Overview

The MLSC launched the Accelerating Research through Collaboration (ARC) Awards to accelerate the research of pressing life science questions through collaboration and to attract and train scientists in the Commonwealth. These public-private partnerships are collaborations between not-for-profit applicants and at least one for-profit Massachusetts life science company. These awards provide approximately $750,000 to cover direct costs and require the hiring of a postdoctoral scientist.

There are 3 tracks for the ARC Awards:

Bits to Bytes

As the leading life sciences ecosystem, Massachusetts recognizes that the role of data sciences in life science innovation has rapidly evolved and has the potential to catalyze that innovation at unprecedented rates. Investment in generating well-annotated datasets and training data scientists for life science research is required to sustain Massachusetts’s global leadership position in life science research and development.

Novel Therapeutics Delivery

The Novel Therapeutics Delivery track fosters the development of novel technologies and techniques for the delivery of existing or innovative therapies by working at the intersection of engineering, biology, chemistry, and medicine. Specifically, it strives to capitalize and incentivize translational projects to address complex challenges in “therapeutic” delivery – from biomanufacturing, to targeted delivery, to biomaterials, medical devices and more.

Women’s Health

This track supports collaborative projects that aim to improve the discovery, technical innovation, and/or analysis of datasets to answer pressing life science questions around women’s health. It incentivizes translational projects that develop novel solutions to treat conditions that solely or disproportionately affect women or have a different presentation between genders.

 

Application Process

August 2025
November 2025
November 2025
March 2026
May 2026
July 2026
Application Period Begins
Application
Due
External Review Period Begin
Review Period
Ends
Award
Notification
Project
Begins

Upcoming Info Sessions

Eligibility and Requirements

The MLSC is investing capital dollars to support equipment and other capital expenses at the not-for-profit partners of these collaborations. Each award will be approximately $750,000 in funding to solve some of the most pressing life science questions in data science, drug delivery, medical devices, or women’s health. Project teams are to be comprised of not-for-profit applicants collaborating with at least one for-profit Massachusetts life science company. All not-for-profit applicants must be a Massachusetts legal entity such as an academic/research institution, hospital engaged in research, or other not-for-profit entity that would be eligible for capital funding from the Commonwealth of Massachusetts. The team must commit to making all purchased equipment and generated data (including metadata and necessary tools) under this award publicly available.
For this solicitation, the MLSC is particularly interested in supporting the following applications:
Top applicants may be asked to present their proposed project plan to our review panel.

Program Resources

Please note that the submission system only allows one active application per grant program at a time for each user account. It is possible to have an active application across multiple programs, as well as submit applications for the same program sequentially.

Utilize our Research Equipment Database where you can search the equipment that MLSC has funded, all of which are available to external researchers.

Search our D.A.T.A. repository for the datasets, algorithms, and codebases generated with MLSC funds made publicly available.

Impact on the Ecosystem

Over the past six years, the MLSC has awarded $47.2 million in capital funding through 3 tracks of the ARC Awards. Approximately, $750,000 in funding per project has gone to 65 cross-sector projects focused on imaging, cancer, neuroscience, drug discovery/delivery, women’s health, and many other healthcare sectors that develop capital assets, data resources, and novel algorithms to address a myriad of health issues. The success of these projects has led to over $145 million in follow-on funds, 250 publications, and 30 patents filed. Additionally, these projects train the next generation of post-doctoral scientists. The non-profit and industry partners on these projects have contributed more than $78 million in funds.

Learn more about our prior awardees from 2019, 2020, 2021, 2022, 2023, and 2024,  including the principal investigator, industry partners, and the innovative projects.

Connect with us to learn more

If you have any questions regarding the application process, e-mail: mlscindustryprograms@masslifesciences.com.
Corner Splash 01 scaled 1 1

Other Programs

Solid Swoop 01 scaled 1 1

Join the Heart of the Hub

Sign up for The Beat our weekly newsletter

  • This field is for validation purposes and should be left unchanged.
Research Infrastructure and Equipment

Research Infrastructure and Equipment

Research Infrastructure and Equipment

The MLSC is running two programs designed to provide grants for capital projects that support the life sciences ecosystem in Massachusetts by enabling and supporting life sciences research and development in the Commonwealth.

The application period will run from Aug. 5 – Nov. 21, 2025 at 1 p.m. EST.

Program Overview

The MLSC is running two programs designed to provide grants for capital projects that support the life sciences ecosystem in Massachusetts by enabling and supporting life sciences research and development in the Commonwealth. The two programs are the Research Infrastructure Program and the Research Equipment Program.

Research Infrastructure: Capital dollars are available to support capital projects ranging from $1.5 – $5 million to establish critical research resources across the state for not-for-profit organizations. Applicants will have to demonstrate how the requested infrastructure will benefit the entire life sciences ecosystem in Massachusetts.

Research Equipment: Capital dollars are available to support research equipment up to $500,000 across the state for not-for-profit organizations. Applicants will have to demonstrate how the requested piece(s) of equipment will benefit the entire life sciences ecosystem in Massachusetts.

Upcoming Info Sessions

Eligibility & Evaluation

Applicants must be a Massachusetts legally organized “not-for-profit” entity such as an academic/research institution, a hospital engaged in research, business incubator or accelerator, or other not-for-profit entity that would be eligible for capital funding from the Commonwealth of Massachusetts. Institutions that are exclusively health care providers and/or requests for the purchase of equipment associated with standard healthcare would not be eligible for capital funding.


Eligible applicants must meet the following criteria:

Applications must be submitted online. The MLSC staff will conduct an initial screening for application completeness and then submit applications to a panel of external experts for review. Applicants may receive invitations to present their proposals to address questions or provide clarification. The MLSC will provide final recommendations to its Board of Directors for approval.

Program Resources

Please note that the submission system only allows one active application per grant program at a time for each user account. It is possible to have an active application across multiple programs, as well as submit applications for the same program sequentially.

Impact on the Ecosystem

Massachusetts recognizes that investment in capital projects and infrastructure is required to create and sustain the attributes that make Massachusetts attractive to innovation clusters.  To date, the MLSC has awarded or committed more than $615 million to support capital research infrastructure projects across the state.

Learn more about the 2020, 2021, 2022, 2023, and 2024 Research Infrastructure awardees.

Connect with us to learn more

If you have any questions regarding the application process, e-mail: ResearchInfrastructure@masslifesciences.com.
Corner Splash 01 scaled 1 1

Other Programs

Solid Swoop 01 scaled 1 1

Join the Heart of the Hub

Sign up for The Beat our weekly newsletter

  • This field is for validation purposes and should be left unchanged.
Frontiers Program

Frontiers Program

Frontiers Program

Investing in Bold Science to Close the Gaps in Discovery

The application period will run from Aug. 5 – Nov. 21, 2025 at 1 p.m. EST.

Program Overview

The Frontiers Program supports early-stage, high-risk translational research in areas that have historically lacked investment proportional to disease-burden but offer extraordinary promise for patients. Through a phased investment model, the Massachusetts Life Sciences Center (MLSC) aims to de-risk innovation and catalyze long-term impact in areas with high unmet need and social burden.

This program advances our commitment to health equity, scientific inclusivity, and public-private partnership by directing resources to drive innovation in these overlooked research domains, thereby accelerating scientific breakthroughs, attracting further investment, and ultimately delivering transformative solutions to patients who have long been underserved.

Award Structure

The Frontiers Fund will offer phased awards that increase over time based on progress milestones:

Phase
Focus
Capital Funds
General Funds
Time
Phase I
Feasibility & early data
Up to $100,000
Up to $100,000
1 Year
Phase II
Translational validation
Up to $400,000
Up to $200,000
2 Years
Phase III
Partnership readiness
Up to $250,000
Up to $100,000
1 Year

Key Focus Areas

The Frontiers Program will support translational research proposals in one or more of the following fields, that have not received proportional investment but hold immense promise for patient and societal benefit:

Upcoming Info Sessions

Eligibility and Evaluation

Applicants must be:

Program Resources

Please note that the submission system only allows one active application per grant program at a time for each Submittable user account. It is possible to have an active application across multiple programs, as well as submit applications for the same program sequentially. 

Impact on the Ecosystem

The Frontiers Program is designed to unlock transformative potential across the Massachusetts life sciences ecosystem by channeling resources into fields that have been stuck in the starting line due lack of value-based investment.

By supporting translational research in critical areas like mental health, antimicrobial resistance, and health equity, the program strengthens the pipeline of innovation, stimulates cross-sector collaboration, and ensures that the benefits of scientific progress reach broader and more diverse patient populations. This strategic investment not only bridges gaps in discovery but also reinforces Massachusetts’ leadership in inclusive, future-facing life sciences research.

Connect with us to learn more

If you have any questions regarding the application process, e-mail: mlscindustryprograms@masslifesciences.com.
Corner Splash 01 scaled 1 1

Other Programs

Solid Swoop 01 scaled 1 1

Join the Heart of the Hub

Sign up for The Beat our weekly newsletter

  • This field is for validation purposes and should be left unchanged.
BioBoost

BioBoost

Hero Swoop blue 03

BioBoost

Massachusetts is a global leader in life science research and development. The Commonwealth also has a strong growing manufacturing presence. Many of the world’s top biotech, pharma, and medtech companies have chosen to co-locate their R&D and manufacturing operations in Massachusetts to take advantage of the density of talent, collaborative spirit, and opportunities for consistent iteration between the lab and production teams. These close collaborative connections work even better on the cutting-edge innovations when the manufacturing processes are nimble, creative, and responsive to the lightning speed of science.

The application period will run from Sept. 15 – Nov. 21, 2025 at 1 p.m. EST.

Program Overview

The MLSC’s BioBoost Manufacturing Scale-Up program supports companies creating or expanding their biomanufacturing or medtech advanced manufacturing presence in Massachusetts. This program aims to be a responsive and adaptive tool to fund capital investments, such as buildout, renovation, or equipment needs in a way that best meets current and future industry needs to support increased manufacturing activity and career development in Massachusetts. The BioBoost program will award funding of up to $3,000,000 per project in capital funding to support life science companies or partner nonprofits that can build or scale new manufacturing operations in Massachusetts. Separately, the BioBoost program will award funding of up to $500,000 per project to support real estate developers’ site readiness study or other planning/evaluation needs to develop a particular target property for life science manufacturing use.

Funding will be given to projects that can demonstrate a broader public benefit and contribute to the larger life sciences ecosystem including workforce training space and programming, offering access or discounts to small local companies, or collaboration with nonprofit partners.

The MLSC anticipates awarding up to three grants for direct manufacturing scale-up between $1,000,000 and $3,000,000 for two (2) years of work. The MLSC anticipates awarding one to two grants for real estate developer evaluation between $250,000 and $500,000 for one (1) year of work.

Upcoming Info Sessions

Eligibility and Evaluation

Company or non-profit applicants must use funds to create or expand biomanufacturing or medtech advanced manufacturing operations within Massachusetts, such as funding buildout, renovation, or equipment needs. Real estate developer applicants must use funds to conduct feasibility studies or otherwise assess specific site readiness for potential life science manufacturing purposes.

Applicants must be a:

Application

Applicants are required to create an account prior to accessing the application. If you already have an account, please log in to begin the application.

Frequently Asked Questions

What size company is BioBoost targeting?

BioBoost is open to life sciences companies of any size, based in Massachusetts or looking to expand to Massachusetts. BioBoost is also open to non-profit organizations, community colleges, universities, real estate developers, and municipalities.

Preference would be given for biomanufacturing or medtech advanced manufacturing operations that:

  • Included an on-site training space co-operated by a non-profit training provider
  • Partnered with a Massachusetts non-profit for research or equipment access
  • Offered support, access, or discounts to Massachusetts startups, students, or entrepreneurs
  • Partnered with a local school to support STEM education utilizing some part of the facility
      •  

Impact on the Ecosystem

The BioBoost program was created to support life science companies seeking to manufacture their products in close proximity to their successful R&D operations, as well as to meet the needs of industry surveyed and evaluated in the spring of 2025, informed by recent shifts in the global economy and national focus.

Massachusetts has invested significantly in workforce development programs, such as Pathmaker, to support a diverse talent pipeline for skilled biomanufacturing and advanced manufacturing workers.

Connect with us to learn more

If you have any questions regarding the application process, e-mail: bioboost@masslifesciences.com.
Corner Splash 01 scaled 1 1

Other Programs

Solid Swoop 01 scaled 1

Join the Heart of the Hub

Sign up for The Beat our weekly newsletter

  • This field is for validation purposes and should be left unchanged.
Biobank

Biobank

Biobank

The MLSC is building a Biobank program to accelerate patient-centric research.

The MLSC Biobank program is in stage 2, seeking proposals by Oct. 3, 2025 at 5 p.m. EST.

Program Overview

The life science ecosystem thrives on access to patient samples and data for breakthrough, patient-centric research. Yet, many researchers face significant barriers, including institutional restrictions and inconsistent protocols. The MLSC Biobank program is designed to break these barriers by establishing disease-specific, accessible biobanks sourced from diverse patient populations across Massachusetts.

By tackling patient sample and data access challenges, this initiative empowers startups, mid-sized companies, pharmaceutical firms, and translational researchers to drive innovation in diagnostic and therapeutic development.

Based on our ecosystem-wide Phase 1 survey, we have identified Alzheimer’s Disease and Colorectal Cancer as the disease areas of focus for the first round of the program. Partnering with institutions statewide, the goal is to create a broadly usable biobank that benefits both non-profit and for-profit institutions seeking high-quality patient samples and data.

Key Focus Areas

Upcoming Info Sessions

Phase Approach

Phase 1
Phase 2
Phase 3

Disease survey for
need assessment
Patient recruitment
Cataloging and storage
Data generation

Distribution of data
and samples

Disease Areas for 2025-2026

  1. Colorectal Cancer 
  2. Alzheimer’s Disease 

The MLSC completed Phase 1 of gathering insights from startups and translational researchers to determine the first-year disease focus. In Phase 2, we are seeking proposals for the following section of the MLSC Biobank program:

Sample Collection and Medical Data Consolidation:
We invite academic medical centers (AMCs) and other non-profit patient care centers in Massachusetts to serve as centers for sample and medical data collection for Colorectal Cancer and Alzheimer’s Disease.

Please indicate your intent to participate using the form below by Oct. 3, 2025 at 5 p.m. EST. View sample form.

Impact on the Ecosystem

Access to diverse, well-characterized patient samples is critical for biomedical innovation. The MLSC Biobank program will ensure accelerated patient-centric research where novel biomarker discoveries, patient registries, and new therapeutics are developed with the needs of all patient populations in mind.

This initiative’s immediate impact will be on the startup and research ecosystem with access to well-curated data and samples to accelerate their therapeutic research. Long term impact will be the generation of a sustainable, standardized and diverse disease focused biobank that ensures safe and optimal use of patient samples and data.

Impact on the Ecosystem

Access to diverse, well-characterized patient samples is critical for biomedical innovation. The MLSC Biobank Program will ensure accelerated patient centric research where novel biomarker discoveries, patient registries, and new therapeutics are developed with the needs of all patient populations in mind.

This initiative’s immediate impact will be on the startup and research ecosystem with access to well-curated data and samples to accelerate their therapeutic research. Long term impact will be the generation of a sustainable, standardized and diverse disease focused biobank that ensures safe and optimal use of patient samples and data.

Disease Area Focus Survey

The MLSC Biobank program is in stage one. We invite researchers, startups, and industry leaders to take our survey below to help determine the specific diseases that will be prioritized.

Connect with us to learn more

If you have questions regarding the survey or the program in general, please email: Biobank@masslifesciences.com.

Corner Splash 01 scaled 1 1

Other Programs

Solid Swoop 01 scaled 1

Join the Heart of the Hub

Sign up for The Beat our weekly newsletter

  • This field is for validation purposes and should be left unchanged.
Women’s Health Initiative

Women’s Health Initiative

Hero Swoop Purple 01

Women’s Health Initiative

Targeted Research. Coordinated Action. Better Health for All. 

The Current State: From high blood pressure, to depression, to autoimmune conditions, women are suffering at higher rates from many illnesses and diseases. Furthermore, exclusion of women from clinical trials and a lack of organized capital have hampered our understanding of any sex-based variation in diseases that present across genders [1,2].


The Challenge: This has resulted in a general underrepresentation and lack of focus on women’s health. Not understanding and studying these nuances impacts not only patients, but also employers and the healthcare system.

The application period will run from Aug. 5 – Nov. 21, 2025 at 1 p.m. EST.

Funding Inequities in Women's Health Research

Funding for conditions that predominantly affect women is insufficient. However, increasing investment could lead to significant benefits. Use the buttons below to explore the data. For the best experience, we recommend viewing this on larger screens, such as desktops.

Women are
50-75%
more likely than men to have an adverse drug reaction across all therapeutic indications [3].

80%
of drugs that have been pulled from the market over safety concerns are due to adverse effects specifically in women.

Working Toward Solutions

While some progress has been made, from increased female participation in clinical trials to women’s health in general being better defined, more work remains [4].

The MLSC aims to support and incentivize translational project teams developing novel solutions in this area of need. The Center’s Women’s Health Initiative strives to turn the tide against the severe lack of organized capital and incentives around a coordinated Women’s Health approach.

With continued strategic investment in this area, Massachusetts is poised to become the leader in the Women’s Health space. 

Program Overview

The MLSC Women’s Health Initiative is a bold funding program launched in 2019 designed to close critical gaps in scientific understanding and clinical care for the most pressing and under-researched conditions that affect women solely, disproportionately, or differently. Despite their impact on millions of lives, many of these conditions remain underfunded and poorly understood. This initiative seeks to change that.

Through a rotating focus on specific disease areas, the initiative ensures that a broad spectrum of women’s health topics are addressed over time. For the current cycle, the spotlight is on Pregnancy-Induced Hypertension and Perimenopause/Menopause—two prevalent but neglected areas in biomedical research.

At the heart of the program is a pillar-based research model designed to foster innovation through collaboration. Each disease area is explored across four integrated pillars ensuring a comprehensive, translational approach:

AI and Data Science
Harnessing the power of artificial intelligence, predictive modeling, and big data to identify patterns, improve diagnosis, and uncover new research questions. 

Disease Biology 
Investigating the fundamental mechanisms of disease, including hormonal, genetic, and molecular drivers, to build a foundation for targeted therapies. 

Research and Development 
Advancing preclinical and translational research aimed at developing novel diagnostics, interventions, and therapeutic strategies. 

Clinical Adoption
Bridging research and practice by identifying pathways to integrate discoveries into clinical settings and improve patient outcomes. 

Approximately $3 million in capital funding is available for each disease focus area (up to $6 million in total funding). Awards will support collaborative Massachusetts-based research across these domains. 

Application Process

August 2025
November 2025
November 2025
March 2026
May 2026
July 2026
Application Period Begins
Application
Due
External Review Period Begin
Review Period
Ends
Award
Notification
Project
Begins

Disease Focus Areas

Despite their prevalence and profound impact on quality of life, pregnancy-induced hypertension and perimenopause/menopause remain vastly under-researched and poorly understood. This round’s disease focus areas aim to reverse that trend by investing in targeted science, coordinated strategy, and sustained collaboration. Bringing together these four pillars will create meaningful steps forward in these target fields. 

Pregnancy-Induced Hypertension

Including conditions such as gestational hypertension, preeclampsia, and postpartum preeclampsia, this area seeks to uncover the causes, predictive markers, and optimal interventions for hypertension during pregnancy—conditions that carry serious risks for both parent and child. 

Perimenopause & Menopause 

This research track focuses on the biological transition women experience in midlife, including its impact on cardiovascular, cognitive, and metabolic health—an area historically underfunded and underserved in biomedical research. 

Collaborative Team Model

Applicants will join one of the four pillar-based research teams within their disease focus area. These interdisciplinary teams will work in a coordinated fashion to accelerate understanding, innovation, and implementation—ensuring that progress in one area informs and amplifies others. Although grants are awarded directly to institutions, funded projects are not isolated efforts—they are part of a coordinated ecosystem.

To promote synergy and maximize scientific return, projects within each pillar will actively engage through structured collaboration. This includes:

This structure ensures that progress in one area informs and amplifies efforts across the entire research landscape—from lab bench to clinic. By breaking down silos and uniting multidisciplinary teams, the MLSC Women’s Health Initiative aims to deliver meaningful and lasting advances in women’s health.

Join the MLSC’s Women’s Health Initiative WhatsApp online community. To request access to join and be part of a growing network advancing Women’s Health in Massachusetts, please complete this request form.

The MLSC is hosting an online community to facilitate collaboration relevant to the Women’s Health Initiative. Joining the online community is voluntary and will not impact eligibility or participation in any MLSC funding opportunities. The MLSC will moderate the group chat with respect to invitations to join and maintaining a respectful community. Please do not share confidential, proprietary, or legally protected information in the online community. The WhatsApp group is not an official channel for conducting MLSC business. Additional information will be provided on the WhatsApp Group home page.

Upcoming Info Sessions

Upcoming Teaming Meetings

The MLSC will host virtual Teaming Meetings that aim to connect researchers, clinicians, and public health leaders from Massachusetts-based not-for-profit research institutions. These events are geared towards the creation of collaborative teams developing innovative approaches to address this round’s disease focus areas across four key pillars. Participants will also learn about the Women’s Health Initiative and upcoming funding opportunities.

Become a Sponsor

Companies that are interested in becoming a sponsor should contact the MLSC staff to discuss further. Please contact WomensHealth@masslifesciences.com

Eligibility and Requirements

Eligible applicants must meet the following criteria:

For this solicitation, the MLSC is particularly interested in supporting the following applications from applicants that meet these eligibility parameters:

Note: Industry sponsors of this program will receive access to the data and information resulting from research by Awardees as well as a non-exclusive, worldwide royalty-free license, with the right to sublicense to its affiliates, to any Intellectual Property resulting from the research by Awardees for internal research purposes only. Industry sponsors may negotiate other Intellectual Property and corporate ownership rights and/or licenses with Awardee independently of the Women’s Health Initiative. See the Deliverables, Confidentiality, and General Conditions for more information.

Program Resources

Search our D.A.T.A. repository for the datasets, algorithms, and codebases generated with MLSC funds made publicly available.

Upcoming Team Meetings

Impact on the Ecosystem

The MLSC has deployed more than $19 million across 60 projects in collaboration with 15 companies, fostering advancements in translational research. Together, we can reshape the future of women’s health. 

Learn more about past awardees of programs under the MLSC Women’s Health Initiative here: First Look, Women’s Health Innovation, Women’s health Collaboration.

The MLSC has deployed more than $19 million across 60 projects in collaboration with 15 companies, fostering advancements in translational research.

$ 0 Million

invested by the MLSC to support

0 Projects
$ 0 Million

in follow-on funding received

References:
[1] Estimates of Funding for Various Research, Condition, and Disease Categories. NIH RePORT. 2022. https://report.nih.gov/funding/categorical-spending#/
[2] Mirin, A. Gender Disparity in the Funding of Diseases by the U.S. National Institutes of Health. Journal of Women’s Health 2021 30:7, 956-963
[3] Tharpe, N. Adverse drug reactions in women’s health care. J Midwifery Womens Health. 2011 56(3):205-13. PMID: 21535369.
[4] Vasquez-Avila, K. Addressing the critical role of gender identity and sex in the planning, analysis, and conduct of clinical trials. Princ Pract Clin Res. 2021;7(2):59-62. PMID: 34532571.

Connect with us to learn more

If you have questions regarding the application process, e-mail WomensHealth@masslifesciences.com  with “Women’s Health Initiative” in the subject line.

Other Programs

Solid Swoop 01 scaled 1

Hear from the Heart of the Hub

Sign up for The Beat our weekly newsletter.

  • This field is for validation purposes and should be left unchanged.
Internship Programs

Internship Programs

Hero Swoop blue 03

Internship Programs

Investing in the next generation of life science professionals is at the core of our mission. Our internship programs enhance the talent pipeline for the Massachusetts life sciences industry by creating hundreds of new internship opportunities each year for high school students, college students and recent graduates interested in life sciences careers.

The MLSC is excited to announce that applications are now open for the 2024 Internship Challenge, High School Apprenticeship Challenge, and Data Science Internship program.

For our future life sciences leaders

The life sciences pairs life-changing careers which contribute to finding cures and treatments to transform lives alongside career growth opportunities to provide financial well-being. There has never been a better time to join the life sciences field. An internship could be a first step to a thriving career in a booming sector that impacts patients around the world.

For our fast-growing organizations

Internships help cultivate a workforce pipeline our companies deserve. The MLSC’s programming has expanded the pool of prospective employees who have practical experience, increased opportunities for mentoring, and enabled more students from across the Commonwealth to explore careers in the life sciences industry.

For our colleges/universities and high schools

Massachusetts is known as the talent capital of the world in no small part because of our innumerable, highly renowned colleges and universities. Massachusetts higher education institutions understand the power of pairing their degree programs with experiential learning and hands-on training opportunities.

Creates hundreds of new internship opportunities each year for college students interested in pursuing careers in the industry. The program connects Massachusetts companies with students and provides funding that enables small companies, with 100 or fewer employees, to hire paid interns for up to 12 weeks.

MassBioCareer
2 High School Apprenticeship Students working in lab together.

Facilitates and funds paid internships for underrepresented and low-income high school students throughout Massachusetts. The program also offers a pre-internship lab training program for some school districts that provides rigorous biotechnology/biomedical and professional skills development.

Focuses on increasing the availability of advanced analytics/data science talent in the life sciences. The program creates new internship opportunities for qualified candidates, including those at the Bachelor’s, Master’s, and Doctoral levels by enabling research institutions and small life sciences companies to hire paid interns for up to four months.

Advanced Analytics Data Science Internship Program

Internship Program Partners

As part of our commitment to increasing diversity, equity, and inclusion in the life sciences workforce, the MLSC also partners with Project Onramp and the UNCF Ernest E. Just Initiative to support internship opportunities for underrepresented students.

The MLSC is proud to partner with the United Negro College Fund (UNCF) on the Ernest E. Just Life Sciences Initiative, which creates internship opportunities in the Boston-area for students enrolled in Historically Black Colleges and Universities (HBCUs) and other Minority Serving Institutions (MSIs). Students gain valuable experience and a network of professionals to pave a path for a fulfilling career in the life sciences.

The program creates paid summer internships for Massachusetts college students who are under-resourced and often first-generation, helping to bridge the opportunity gap for these promising young people. Project Onramp also provides wraparound training and support for interns and their supervisors.

MLSC Internship Success Stories

Funding Impact

Since its creation in 2007, the Massachusetts Life Sciences Center has strategically deployed more than $700 million in Massachusetts, through a combination of grants, loans, capital infrastructure investments, tax incentives, and workforce programs. These investments have created thousands of jobs and propelled the development of new therapies, devices, and scientific advancements that are improving patient health and well-being in Massachusetts and around the world.

Invested more than

$ 0 M

in the ecosystem.

Rising arrows 01
0 +

internships supported.

Employment

Over

0 K
0

jobs created.

$ 0 M+
Microscope 1

in STEM equipment and professional development.

Team Massachusetts is excited to connect you with the latest and most relevant resources available for businesses. We’re here to support you every step of the way as your company grows. Through the Business Front Door, we can make your business journey in Massachusetts a successful one.
Business Front Door Logo

Connect with us to learn more

If you have further questions regarding the application process, please email: internship@masslifesciences.com.

Corner Splash 01 scaled 1

Other Programs

Solid Swoop 01 scaled 1

Hear from the Heart of the Hub

Sign up for The Beat our weekly newsletter

  • This field is for validation purposes and should be left unchanged.
Women’s Health Collaboration Program

Women’s Health Collaboration Program

Hero Swoop Purple 02

The application period will run from Aug. 5 – Nov. 21, 2025 at 1 p.m. EST.

Program Overview

The Women’s Health Collaboration Program is part of the MLSC’s Accelerating Research through Collaboration (ARC) Awards. This program supports collaborative projects that aim to improve the discovery, technical innovation, and/or analysis of datasets to answer pressing life science questions around women’s health. It incentivizes translational projects that develop novel solutions to treat conditions that solely or disproportionately affect women or have a different presentation between genders.

Application Process

August 2025
November 2025
November 2025
March 2026
May 2026
July 2026
Application Period Begins
Application
Due
External Review Period Begin
Review Period
Ends
Award
Notification
Project
Begins

Eligibility and Requirements

Project teams are to be comprised of not-for-profit applicants collaborating with at least one for-profit Massachusetts life science company. All not-for-profit applicants must be a Massachusetts legal entity such as an academic/research institution, a hospital engaged in research, a business incubator or accelerator, or other not-for-profit entity eligible for capital funding from the Commonwealth of Massachusetts. Institutions that are exclusively health care providers and/or requests for the purchase of equipment associated with standard healthcare delivery would not be eligible for capital funding.

Applications must be submitted online. The MLSC staff will conduct an initial screening for application completeness and then submit applications to a panel of external experts for review. Applicants may receive invitations to present their proposals to address questions or provide clarification. The MLSC will provide final recommendations to its Board of Directors for approval. 

Program Resources

Please note that the submission system only allows one active application per grant program at a time for each user account. It is possible to have an active application across multiple programs, as well as submit applications for the same program sequentially.

Corner Splash 01 scaled 1 1
CellCorners Red

Impact on the Ecosystem

Massachusetts recognizes there has been a lack of development in novel solutions to treat conditions that solely or disproportionately affect women or have a different presentation between genders. This impacts not only patients, but also employers and the healthcare system. The consequences are profound, with women more likely to have adverse drug reactions than men, and the lack of effective therapies results in reduced quality of life. The Massachusetts Life Sciences Center aims to support and incentivize translational project teams developing novel solutions in this area of need. Over the past six years, the MLSC has awarded $10 million in capital funding through the Women’s Health Collaboration program.

Learn more about the 202020212022, 2023, and 2024 Women’s Health awardees, including the principal investigator, industry partners, and the innovative projects.

$ 0 M

in MLSC investments

$ 0 M
Microscope 1

in leveraged academic & industry funding

0

MA non-profit organizations & industry partners

Handshake
$ 0 M

follow-on funding received

Connect with us to learn more

If you have questions regarding the application process, e-mail WomensHealth@masslifesciences.com.

Other Programs

Solid Swoop 01 scaled 1

Hear From the Heart of the Hub

Sign up for The Beat our weekly newsletter

  • This field is for validation purposes and should be left unchanged.
Pathmaker

Pathmaker

Hero Swoop blue 03

Pathmaker

A Pathway to a Life Science Career

The MLSC Pathmaker program funds industry-aligned training programs that address critical skills and talent supply gaps and connects skilled, diverse workers with life science career opportunities in Massachusetts.

This program is currently accepting applications.

Who is Pathmaker For?

Cell Split Partial 01 scaled 1

Pathmaker for Career Seekers

There is no better time for those interested in a career in the life sciences. This is a sector full of companies of all sizes with missions that truly change lives on a global scale. Starting salaries and paths for further career development in the life sciences represent unique opportunities for growth. No prior scientific work experience or higher education credentials needed. Learn about free training programs today.

Navy MLSC Pathmaker Certification Seals 01
Cell Split Partial Navy 01 scaled 1

Pathmaker for Training Organizations

Pathmaker will award direct funding to support organizations that can build and scale career pathways that effectively prepare students for high-demand career opportunities in the life sciences. The program also aims to provide already existing programs a “stamp of validation” for efforts that meet the most up-to-date industry criteria.

Navy MLSC Pathmaker Certification Seals 01
Cell Split Partial 01 scaled 1

Pathmaker for Industry Partners

Pathmaker applicants must have at least one industry partnership that ensures that the program is responding to a direct hiring need. The program aims to leverage and catalyze the excellent workforce development resources in the Commonwealth and grow the talent pipeline and increase connections for employers to skilled, diverse workers in Massachusetts.

Navy MLSC Pathmaker Certification Seals 01

MassTalent Initiative

Pathmaker is a key component of the Healey-Driscoll Administration’s MassTalent initiative, a new strategy for connecting employers to skilled, diverse workers in Massachusetts.

masstalent logo scaled 1

Upcoming Info Sessions

Featured Videos

Impact on the Ecosystem

Pathmaker has grown out of an existing group of successful partnerships between life science companies and training providers that leverage the excellent workforce development resources we have in the Commonwealth and the previous investments the Center and others have made in the ecosystem. Pathmaker was announced in June 2023 at the BIO International Convention as part of the Healey-Driscoll Administration’s launch of a new strategy for connecting employers to skilled, diverse workers in Massachusetts called MassTalent. MassTalent will serve as a one-stop front door for companies to access multiple talent pipelines in high-growth industries like the life sciences, clean energy and advanced manufacturing.

The 2024 MassBioEd Life Science Workforce Analysis Report indicates that:

The additional funding available through this program aims to amplify and scale these successful models to address the most pressing workforce needs in the industry and create a sustainable structure that can adapt to the future needs as the spirit of innovation, collaboration, and entrepreneurship continue to make Massachusetts the best place in the world for the life sciences.

Connect with us to Learn More

If you have any questions please email Pathmaker@masslifesciences.com or click the button below.
Corner Splash 01 scaled 1

Other Programs

Solid Swoop 01 scaled 1

Join the Heart of the Hub

Sign up for The Beat our weekly newsletter

  • This field is for validation purposes and should be left unchanged.
MLSC Brandmark scaled 1

Hear from the Heart of the Hub